Infection Management Guidelines and Outcomes in Severe Sepsis
Infection Management Guidelines and Outcomes in Severe Sepsis
More data on the relationship between time to source control and patient outcome are needed. In the interim, surgical source control should be performed as soon as possible. Adequacy of empirical AT is important for the survival in sepsis, and choice of initial AT is an important decision in the therapy of these patients. There was only indirect evidence about the impact of timing of AT on sepsis mortality but evidence about this issue varies significantly among the available studies. Randomized controlled trials are thus necessary to further elucidate the impact of AT timing on survival. Quality improvement initiatives should not be restricted to severe sepsis but should also focus on the timely recognition and adequate treatment of infections to prevent their progress to severe sepsis.
Conclusions
More data on the relationship between time to source control and patient outcome are needed. In the interim, surgical source control should be performed as soon as possible. Adequacy of empirical AT is important for the survival in sepsis, and choice of initial AT is an important decision in the therapy of these patients. There was only indirect evidence about the impact of timing of AT on sepsis mortality but evidence about this issue varies significantly among the available studies. Randomized controlled trials are thus necessary to further elucidate the impact of AT timing on survival. Quality improvement initiatives should not be restricted to severe sepsis but should also focus on the timely recognition and adequate treatment of infections to prevent their progress to severe sepsis.
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