In this day and age wheelchair-accessible hotel rooms are commonplace.
That said, not all accessible rooms are created equal; so a certain amount of advance research is necessary if you have access needs.
The good news is, there are a wide variety of accessible rooms out there.
With that in mind here are a few things for wheelchair-users and slow walkers to remember when searching for accessible lodging.

• Never just ask for an "accessible" or an "ADA compliant" room.
  Instead, describe the access features you need.
  Access features in rooms vary, and not all accessible rooms have roll-in showers.
  
• Never ask yes or no questions when inquiring about access, as in most cases the answer will always be yes.
  
• Make sure and ask about the availability of elevators if you cannot manage stairs.
  Some roadside hotels do not have elevators, so make sure you get a room on the first floor.
  
• Bed height is not regulated under the Americans with Disabilities Act (ADA), so make sure and ask for measurements.
  Many properties are replacing their standard mattresses with high pillow top and luxury models.
  If the bed is too high for you, ask for a roll-away bed, as they are usually lower.
  
• If you're a slow walker who can't do distances, ask for a first-floor room near the lobby, or a room on another floor near the elevator.
  
• Use MapQuest to locate a property with a restaurant nearby, so you won't have to drive to dinner after a long day in the car.
  Call the restaurant to make sure it is accessible, and that there is a barrier-free path from the motel to the restaurant.
  
• Look for Microtel properties along the way, as they are constructed from the ground up with access in mind.
  They are conveniently located along interstate highways and they also offer very reasonable rates.
  
• Depending on the length of your trip, you may need to plan for a laundry day along the way.
  Try to find a hotel with a guest laundry, as it has a better chance of being accessible than the local laundromat.
  
• If you are staying at city center hotel, ask about parking charges when you book your room.
  Sometimes these fees can be as much as $20 per day.
  Properties outside the city usually have lower rates and free parking.
  
• If you find yourself unable to use the shower in your accessible motel room, then consider stopping by a Pilot - Flying J truck stop the next day.
  They have accessible shower rooms, complete with a roll-in shower, a roll-under sink and a toilet with grab bars.
  There is a charge for using the shower room, however it's a good emergency alternative.
  They also have nice accessible restrooms, which are free.