Multiple Sclerosis
Multiple Sclerosis
Important
It is possible that the main title of the report Multiple Sclerosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Multiple sclerosis is a chronic neuroimmunologic (both the nervous system and the immunological system are involved) disorder of the central nervous system involving the brain, spinal cord and optic nerves. By means of a mechanism not clearly understood, the protective fatty, insulating substance called myelin sheath that covers the nerve is destroyed. The inflammatory attacks that produce the characteristic scarring (plaques or patches) of the myelin sheath occurs randomly, vary in intensity, and at multiple sites. The course of the disease may advance, relapse, remit, or stabilize. The randomness of the location of plaques or patches affects the nerve's ability to transmit information (neurotransmission) and causes a wide range of neurological symptoms, which may vary from person to person.
Recently it has been learned that the nerve fibers themselves, (axons), in addition to the myelin sheaths, are affected by the neuroimmunologic attacks. Damage to the nerve cells may be irreversible. As a result, clinicians recommend early intervention with one of the disease-modifying agents (see below).
WE MOVE (Worldwide Education and Awareness for Movement Disorders)
5731 Mosholu Avenue
Bronx, NY 10471
USA
Tel: (347)843-6132
Fax: (718)601-5112
Email: wemove@wemove.org
Internet: http://www.wemove.org
National Multiple Sclerosis Society
1100 New York Avenue NW
Suite 660
Washington, DC 20005-3934
USA
Tel: (202)408-1500
Fax: (202)408-0696
Tel: (800)344-4867
Email: contactusnmss@nmss.org
Internet: http://www.nationalmssociety.org
American Autoimmune Related Diseases Association, Inc.
22100 Gratiot Ave.
Eastpointe, MI 48021
Tel: (586)776-3900
Fax: (586)776-3903
Tel: (800)598-4668
Email: aarda@aarda.org
Internet: http://www.aarda.org/
NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981
Internet: http://www.ninds.nih.gov/
Consortium of Multiple Sclerosis Centers
359 Main Street
Suite A
Hackensack, NJ 07601
Tel: (201)487-1050
Fax: (201)678-2290
Email: info@mscare.org
Internet: http://www.mscare.org
Multiple Sclerosis Association of America
706 Haddonfield Road
Cherry Hill, NJ 08002
USA
Tel: (856)488-4500
Fax: (856)661-9797
Tel: (800)532-7667
Email: ctalbot@msassociation.org
Internet: http://www.msassociation.org/
Multiple Sclerosis International Federation
3rd Floor Skyline House
200 Union Street
London, SE1 0LX
United Kingdom
Tel: 4402076201911
Fax: 4402076201922
Email: info@msif.org
Internet: http://www.msif.org/en/
Spastic Paraplegia Foundation
5305 Miramar Ln
Colleyville, TX 76034
USA
Tel: (877)773-4483
Email: information@sp-foundation.org
Internet: http://sp-foundation.org
Christopher & Dana Reeve Foundation
636 Morris Turnpike, Suite 3A
Short Hills, NJ 07078
USA
Tel: (973)379-2690
Fax: (973)912-9433
Tel: (800)225-0292
Email: prc@ChristopherReeve.org
Internet: http://www.christopherreeve.org
New Horizons Un-Limited, Inc.
811 East Wisconsin Ave
P.O. Box 510034
Milwaukee, WI 53203
USA
Tel: (414)299-0124
Fax: (414)347-1977
Email: horizons@new-horizons.org
Internet: http://www.new-horizons.org
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/
Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766
Email: getinfo@madisonsfoundation.org
Internet: http://www.madisonsfoundation.org
Autoimmune Information Network, Inc.
PO Box 4121
Brick, NJ 08723
Fax: (732)543-7285
Email: autoimmunehelp@aol.com
European Society for Immunodeficiencies
1-3 rue de Chantepoulet
Geneva, CH 1211
Switzerland
Tel: 410229080484
Fax: 41229069140
Email: esid@kenes.com
Internet: http://www.esid.org
Multiple Sclerosis Foundation
6520 North Andrews Avenue
Ft. Lauderdale, FL 33309-2130
Tel: (954)776-6805
Fax: (954)938-8708
Tel: (800)225-6495
Email: admin@msfocus.org
Internet: http://www.msfocus.org
AutoImmunity Community
Email: moderator@autoimmunitycommunity.org
Internet: http://www.autoimmunitycommunity.org
PLAN Institute for Caring Citizenship
Suite 260 - 3665 Kingsway
Vancouver
British Columbia, V5R 5W2
Canada
Tel: 6044399566
Fax: 6044397001
Email: inquiries@planinstitute.ca
Internet: http://www.planinstitute.ca/?q=learnfromus/library
Child Neurology Foundation
201 Chicago Ave, #200
Minneapolis, MN 55415
USA
Tel: (952)641-6100
Fax: (952)881-6276
Tel: (877)263-5430
Email: jstone@childneurologyfoundation.org
Internet: http://www.childneurologyfoundation.org
It is possible that the main title of the report Multiple Sclerosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms
- MS
- demyelinating disease
- disseminated sclerosis
- primary progressive multiple sclerosis
- relapsing-remitting multiple sclerosis
Disorder Subdivisions
- None
General Discussion
Multiple sclerosis is a chronic neuroimmunologic (both the nervous system and the immunological system are involved) disorder of the central nervous system involving the brain, spinal cord and optic nerves. By means of a mechanism not clearly understood, the protective fatty, insulating substance called myelin sheath that covers the nerve is destroyed. The inflammatory attacks that produce the characteristic scarring (plaques or patches) of the myelin sheath occurs randomly, vary in intensity, and at multiple sites. The course of the disease may advance, relapse, remit, or stabilize. The randomness of the location of plaques or patches affects the nerve's ability to transmit information (neurotransmission) and causes a wide range of neurological symptoms, which may vary from person to person.
Recently it has been learned that the nerve fibers themselves, (axons), in addition to the myelin sheaths, are affected by the neuroimmunologic attacks. Damage to the nerve cells may be irreversible. As a result, clinicians recommend early intervention with one of the disease-modifying agents (see below).
Resources
WE MOVE (Worldwide Education and Awareness for Movement Disorders)
5731 Mosholu Avenue
Bronx, NY 10471
USA
Tel: (347)843-6132
Fax: (718)601-5112
Email: wemove@wemove.org
Internet: http://www.wemove.org
National Multiple Sclerosis Society
1100 New York Avenue NW
Suite 660
Washington, DC 20005-3934
USA
Tel: (202)408-1500
Fax: (202)408-0696
Tel: (800)344-4867
Email: contactusnmss@nmss.org
Internet: http://www.nationalmssociety.org
American Autoimmune Related Diseases Association, Inc.
22100 Gratiot Ave.
Eastpointe, MI 48021
Tel: (586)776-3900
Fax: (586)776-3903
Tel: (800)598-4668
Email: aarda@aarda.org
Internet: http://www.aarda.org/
NIH/National Institute of Neurological Disorders and Stroke
P.O. Box 5801
Bethesda, MD 20824
Tel: (301)496-5751
Fax: (301)402-2186
Tel: (800)352-9424
TDD: (301)468-5981
Internet: http://www.ninds.nih.gov/
Consortium of Multiple Sclerosis Centers
359 Main Street
Suite A
Hackensack, NJ 07601
Tel: (201)487-1050
Fax: (201)678-2290
Email: info@mscare.org
Internet: http://www.mscare.org
Multiple Sclerosis Association of America
706 Haddonfield Road
Cherry Hill, NJ 08002
USA
Tel: (856)488-4500
Fax: (856)661-9797
Tel: (800)532-7667
Email: ctalbot@msassociation.org
Internet: http://www.msassociation.org/
Multiple Sclerosis International Federation
3rd Floor Skyline House
200 Union Street
London, SE1 0LX
United Kingdom
Tel: 4402076201911
Fax: 4402076201922
Email: info@msif.org
Internet: http://www.msif.org/en/
Spastic Paraplegia Foundation
5305 Miramar Ln
Colleyville, TX 76034
USA
Tel: (877)773-4483
Email: information@sp-foundation.org
Internet: http://sp-foundation.org
Christopher & Dana Reeve Foundation
636 Morris Turnpike, Suite 3A
Short Hills, NJ 07078
USA
Tel: (973)379-2690
Fax: (973)912-9433
Tel: (800)225-0292
Email: prc@ChristopherReeve.org
Internet: http://www.christopherreeve.org
New Horizons Un-Limited, Inc.
811 East Wisconsin Ave
P.O. Box 510034
Milwaukee, WI 53203
USA
Tel: (414)299-0124
Fax: (414)347-1977
Email: horizons@new-horizons.org
Internet: http://www.new-horizons.org
Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/
Madisons Foundation
PO Box 241956
Los Angeles, CA 90024
Tel: (310)264-0826
Fax: (310)264-4766
Email: getinfo@madisonsfoundation.org
Internet: http://www.madisonsfoundation.org
Autoimmune Information Network, Inc.
PO Box 4121
Brick, NJ 08723
Fax: (732)543-7285
Email: autoimmunehelp@aol.com
European Society for Immunodeficiencies
1-3 rue de Chantepoulet
Geneva, CH 1211
Switzerland
Tel: 410229080484
Fax: 41229069140
Email: esid@kenes.com
Internet: http://www.esid.org
Multiple Sclerosis Foundation
6520 North Andrews Avenue
Ft. Lauderdale, FL 33309-2130
Tel: (954)776-6805
Fax: (954)938-8708
Tel: (800)225-6495
Email: admin@msfocus.org
Internet: http://www.msfocus.org
AutoImmunity Community
Email: moderator@autoimmunitycommunity.org
Internet: http://www.autoimmunitycommunity.org
PLAN Institute for Caring Citizenship
Suite 260 - 3665 Kingsway
Vancouver
British Columbia, V5R 5W2
Canada
Tel: 6044399566
Fax: 6044397001
Email: inquiries@planinstitute.ca
Internet: http://www.planinstitute.ca/?q=learnfromus/library
Child Neurology Foundation
201 Chicago Ave, #200
Minneapolis, MN 55415
USA
Tel: (952)641-6100
Fax: (952)881-6276
Tel: (877)263-5430
Email: jstone@childneurologyfoundation.org
Internet: http://www.childneurologyfoundation.org
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