Non-Vitamin K Antagonist Anticoagulants and Atrial Fibrillation
Non-Vitamin K Antagonist Anticoagulants and Atrial Fibrillation
In clinical trials, NOACs have demonstrated comparable or better risk reductions for stroke and SEE and for bleeding compared with warfarin. In particular, they all significantly reduce the risk for ICH. Patients treated with NOACs are projected to have fewer clinical events and reduced stroke severity, primarily due to fewer numbers of ICHs. Further, the use of NOACs provides more options for specific patient groups, depending on their characteristics and concomitant medications. The risk of GI bleeding should be taken under consideration for patients receiving NOACs; however, some patient populations may benefit greatly from the use of NOACs over traditional warfarin therapy.
Conclusions
In clinical trials, NOACs have demonstrated comparable or better risk reductions for stroke and SEE and for bleeding compared with warfarin. In particular, they all significantly reduce the risk for ICH. Patients treated with NOACs are projected to have fewer clinical events and reduced stroke severity, primarily due to fewer numbers of ICHs. Further, the use of NOACs provides more options for specific patient groups, depending on their characteristics and concomitant medications. The risk of GI bleeding should be taken under consideration for patients receiving NOACs; however, some patient populations may benefit greatly from the use of NOACs over traditional warfarin therapy.
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