White Matter

• White matter is located in the central and subcortical regions of the cerebral and cerebellar hemisphere of the brain. White matter makes up 60 percent of the total brain volume, and can be identified in a scan from its white color, compared to gray matter. There is not as large a supply of blood in the white matter as there is in gray matter, and thus is more susceptible to ischemia. White matter contains the major commissural tracts, cortical association fibers, and all cortical afferent and efferent fibers.
  
  

Visual Problems

• A variety of different visual problems can arise from white matter brain diseases. Examples include blurred vision, double vision and abnormal pupil responses. In addition, patients may also have problems controlling their eye movements, such as lack of coordination or jerky movement of the eyes.
  
  

Motor Problems

• White matter brain disease patients may also have difficulty with motor responses and movement. Types of motor problems include muscle weakness and wasting, paralysis---either mild, partial or total, stiffness, twitching and other involuntary jerking motions, involuntary leg movements, loss of coordination, restricted movement of the limbs, slow movement of the limbs, dragging of the limbs and problems with posture.
  
  

Sensory Problems

• Sensory problems can also occur when there is damage to the white matter. These include numbness, strange sensations such as tingling or vibrations, loss of sensation, experiencing pain without a cause and losing the awareness of limb location.
  
  

Cognitive Problems

• Finally, white matter brain disease can interfere with cognitive functions. Examples of cognitive problems as a result of white matter brain disease are short-term and long-term memory problems, slow word recall, speech impairment, depression, mood swings, anxiety and other mood disorders. Other cognitive problems include sleep disorders, fatigue and impairments to speech comprehensive and production.