HT Does Not Affect Cognition in Younger WHI Women
HT Does Not Affect Cognition in Younger WHI Women
Espeland MA, Shumaker SA, Leng I, et al; for the WHIMSY Study Group. Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med. 2013 June 24. [Epub ahead of print] Level of evidence: II-1.
Researchers examined the effect of conjugated equine estrogens (CEEs) on cognitive function when initiated in postmenopausal women aged 50 to 55 years. The study population of 1,326 women from the Women's Health Initiative (WHI) trials (using 0.625 mg CEE with or without 2.5 mg medroxyprogesterone acetate [MPA] over a mean of 7.0 years) was assessed for cognitive function with telephone-administered tests measuring global and domain-specific cognition. Testing occurred after an average of 7.2 years, when the women were a mean of 67.2 years old, and was repeated 1 year afterwards.
Primary outcome was global cognitive function, and secondary outcomes were verbal memory, attention, executive function, verbal fluency, and working memory. Results were similar among women assigned to CEE and women assigned to placebo. No overall differences were found for any cognitive domain. CEE produced neither benefit nor risk to cognitive function.
Summary
Espeland MA, Shumaker SA, Leng I, et al; for the WHIMSY Study Group. Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med. 2013 June 24. [Epub ahead of print] Level of evidence: II-1.
Researchers examined the effect of conjugated equine estrogens (CEEs) on cognitive function when initiated in postmenopausal women aged 50 to 55 years. The study population of 1,326 women from the Women's Health Initiative (WHI) trials (using 0.625 mg CEE with or without 2.5 mg medroxyprogesterone acetate [MPA] over a mean of 7.0 years) was assessed for cognitive function with telephone-administered tests measuring global and domain-specific cognition. Testing occurred after an average of 7.2 years, when the women were a mean of 67.2 years old, and was repeated 1 year afterwards.
Primary outcome was global cognitive function, and secondary outcomes were verbal memory, attention, executive function, verbal fluency, and working memory. Results were similar among women assigned to CEE and women assigned to placebo. No overall differences were found for any cognitive domain. CEE produced neither benefit nor risk to cognitive function.
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