Indoor Environmental Exposures and Exacerbation of Asthma
Indoor Environmental Exposures and Exacerbation of Asthma
Background Previous research has found relationships between specific indoor environmental exposures and exacerbation of asthma.
Objectives In this review we provide an updated summary of knowledge from the scientific literature on indoor exposures and exacerbation of asthma.
Methods Peer-reviewed articles published from 2000 to 2013 on indoor exposures and exacerbation of asthma were identified through PubMed, from reference lists, and from authors' files. Articles that focused on modifiable indoor exposures in relation to frequency or severity of exacerbation of asthma were selected for review. Research findings were reviewed and summarized with consideration of the strength of the evidence.
Results Sixty-nine eligible articles were included. Major changed conclusions include a causal relationship with exacerbation for indoor dampness or dampness-related agents (in children); associations with exacerbation for dampness or dampness-related agents (in adults), endotoxin, and environmental tobacco smoke (in preschool children); and limited or suggestive evidence for association with exacerbation for indoor culturable Penicillium or total fungi, nitrogen dioxide, rodents (nonoccupational), feather/down pillows (protective relative to synthetic bedding), and (regardless of specific sensitization) dust mite, cockroach, dog, and dampness-related agents.
Discussion This review, incorporating evidence reported since 2000, increases the strength of evidence linking many indoor factors to the exacerbation of asthma. Conclusions should be considered provisional until all available evidence is examined more thoroughly.
Conclusion Multiple indoor exposures, especially dampness-related agents, merit increased attention to prevent exacerbation of asthma, possibly even in nonsensitized individuals. Additional research to establish causality and evaluate interventions is needed for these and other indoor exposures.
Various allergens, airborne irritants, and infections trigger exacerbation of asthma. Because people spend > 75% of their time indoors (Klepeis et al. 2001), exposures found in the indoor environment are paramount. In 2000, the Committee on the Assessment of Asthma and Indoor Air of the Institute of Medicine (IOM) reviewed and summarized the scientific evidence for relationships between indoor air exposures and the exacerbation and development of asthma (IOM 2000). For exacerbation of asthma, sufficient evidence showed a causal relationship for four exposures and association for five exposures, and limited or suggestive evidence showed association with nine exposures. Since 2000, a substantial amount of research on indoor environmental exposures and exacerbation of asthma has been conducted. In this review we aim to provide a comprehensive update on this topic.
Abstract and Introduction
Abstract
Background Previous research has found relationships between specific indoor environmental exposures and exacerbation of asthma.
Objectives In this review we provide an updated summary of knowledge from the scientific literature on indoor exposures and exacerbation of asthma.
Methods Peer-reviewed articles published from 2000 to 2013 on indoor exposures and exacerbation of asthma were identified through PubMed, from reference lists, and from authors' files. Articles that focused on modifiable indoor exposures in relation to frequency or severity of exacerbation of asthma were selected for review. Research findings were reviewed and summarized with consideration of the strength of the evidence.
Results Sixty-nine eligible articles were included. Major changed conclusions include a causal relationship with exacerbation for indoor dampness or dampness-related agents (in children); associations with exacerbation for dampness or dampness-related agents (in adults), endotoxin, and environmental tobacco smoke (in preschool children); and limited or suggestive evidence for association with exacerbation for indoor culturable Penicillium or total fungi, nitrogen dioxide, rodents (nonoccupational), feather/down pillows (protective relative to synthetic bedding), and (regardless of specific sensitization) dust mite, cockroach, dog, and dampness-related agents.
Discussion This review, incorporating evidence reported since 2000, increases the strength of evidence linking many indoor factors to the exacerbation of asthma. Conclusions should be considered provisional until all available evidence is examined more thoroughly.
Conclusion Multiple indoor exposures, especially dampness-related agents, merit increased attention to prevent exacerbation of asthma, possibly even in nonsensitized individuals. Additional research to establish causality and evaluate interventions is needed for these and other indoor exposures.
Introduction
Various allergens, airborne irritants, and infections trigger exacerbation of asthma. Because people spend > 75% of their time indoors (Klepeis et al. 2001), exposures found in the indoor environment are paramount. In 2000, the Committee on the Assessment of Asthma and Indoor Air of the Institute of Medicine (IOM) reviewed and summarized the scientific evidence for relationships between indoor air exposures and the exacerbation and development of asthma (IOM 2000). For exacerbation of asthma, sufficient evidence showed a causal relationship for four exposures and association for five exposures, and limited or suggestive evidence showed association with nine exposures. Since 2000, a substantial amount of research on indoor environmental exposures and exacerbation of asthma has been conducted. In this review we aim to provide a comprehensive update on this topic.
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