Pathophysiology and Treatment of Motion Sickness
Pathophysiology and Treatment of Motion Sickness
Main advances in recent years have been in identifying brain mechanisms and loci that are associated with motion sickness and/or nausea. Similarly, although motion sickness is polysymptomatic, pharmacotherapeutic research has mainly targeted nausea and vomiting, so far, with little advantage over established antimotion sickness drugs. Future development of drugs with highly selective affinities to receptor subtypes relevant to motion sickness may produce an antimotion sickness drug of high efficacy with few side-effects. However, the polysymptomatic nature of motion sickness with its high interindividual variability may preclude a single decisive treatment. In this respect motion sickness is similar to migraine, with which motion sickness is frequently compounded.
Conclusion
Main advances in recent years have been in identifying brain mechanisms and loci that are associated with motion sickness and/or nausea. Similarly, although motion sickness is polysymptomatic, pharmacotherapeutic research has mainly targeted nausea and vomiting, so far, with little advantage over established antimotion sickness drugs. Future development of drugs with highly selective affinities to receptor subtypes relevant to motion sickness may produce an antimotion sickness drug of high efficacy with few side-effects. However, the polysymptomatic nature of motion sickness with its high interindividual variability may preclude a single decisive treatment. In this respect motion sickness is similar to migraine, with which motion sickness is frequently compounded.
Source...