Impact of Bisphosphonates on the Risk of AF
Impact of Bisphosphonates on the Risk of AF
We performed a systematic search of the PubMed database from 1966 to 30 June 2010, drug regulatory websites, and drug manufacturer websites. Search terms included 'atrial fibrillation,' 'bisphosphonates,' 'osteoporosis,' 'arrhythmia,' 'stroke,' 'cardiovascular,' 'adverse events,' and 'safety.' The search was limited to English language articles and human studies. Studies reporting the risk of AF following bisphosphonate exposure were included, as well as findings from systematic meta-analyses. Pertinent review articles were selected and screened for relevant citations. Findings from a total of 16 separate analyses were evaluated for this review, as summarized in table I.
2. Criteria for Literature Search
We performed a systematic search of the PubMed database from 1966 to 30 June 2010, drug regulatory websites, and drug manufacturer websites. Search terms included 'atrial fibrillation,' 'bisphosphonates,' 'osteoporosis,' 'arrhythmia,' 'stroke,' 'cardiovascular,' 'adverse events,' and 'safety.' The search was limited to English language articles and human studies. Studies reporting the risk of AF following bisphosphonate exposure were included, as well as findings from systematic meta-analyses. Pertinent review articles were selected and screened for relevant citations. Findings from a total of 16 separate analyses were evaluated for this review, as summarized in table I.
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