Association of Impaired Fasting Glucose & Diabetes With PAD
Association of Impaired Fasting Glucose & Diabetes With PAD
Peripheral artery disease (PAD) represents a collection of occlusive and aneurysmal diseases affecting the peripheral arteries with an associated high risk of major cardiovascular events and mortality. There are recognised deficiencies in current methods of predicting and limiting complications in PAD patients. Globally, an estimated 382 million people have diabetes and this number will rise to 592 million in 2035. Diabetes is a recognised risk factor for occlusive PAD development but is negatively associated with peripheral aneurysm development. Diabetes has been independently associated with mortality in PAD patients in some but not all studies. Recent data suggest that ~10% of patients presenting with PAD have untreated diabetes and ~17% have impaired fasting glucose. The effect of impaired fasting glucose and untreated diabetes on PAD outcome is unknown. This study aimed to examine the association of impaired fasting glucose, diabetes and their treatments with the presentation, mortality and requirement for intervention of PAD patients.
Background
Peripheral artery disease (PAD) represents a collection of occlusive and aneurysmal diseases affecting the peripheral arteries with an associated high risk of major cardiovascular events and mortality. There are recognised deficiencies in current methods of predicting and limiting complications in PAD patients. Globally, an estimated 382 million people have diabetes and this number will rise to 592 million in 2035. Diabetes is a recognised risk factor for occlusive PAD development but is negatively associated with peripheral aneurysm development. Diabetes has been independently associated with mortality in PAD patients in some but not all studies. Recent data suggest that ~10% of patients presenting with PAD have untreated diabetes and ~17% have impaired fasting glucose. The effect of impaired fasting glucose and untreated diabetes on PAD outcome is unknown. This study aimed to examine the association of impaired fasting glucose, diabetes and their treatments with the presentation, mortality and requirement for intervention of PAD patients.
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